Pulido J. S., I. Sugaya, J. Comstock and K. Sugaya: Reelin expression is upregulated following ocular tissue injuly. Graefe’s Arch Clin Exp Ophthalmol, 2006 Nov 22; [Epub ahead of print]
Roitberg BZ, Mangubat E, Chen EY, Sugaya K, Thulborn KR, Kordower JH, Pawar A, Konecny T, Emborg ME: Survival and early differentiation of human neural stem cells transplanted in a nonhuman primate model of stroke. J Neurosurg. 2006 Jul;105(1):96-102.
Sugaya K, Alvarez A, Marutle A, Kwak YD, Choumkina E: Stem cell strategies for Alzheimer's disease therapy. Panminerva Med. 2006 Jun;48(2):87-96.
I. Sugaya, T. Qu, K. Sugaya and G.D. Pappas: Genetically enginieered human mesenchymal stem cells produce Met-Enkephalin at augmented higher levels in vitro. Cell Transplant. 2006;15(3):225-30.
Kwak, Y-D., H. M. Kim, T. Qu, C. L. Brannen, P, Soba, A. Majumdar, A. Kaplan, K. Beyreuther and K. Sugaya: Amyloid Precursor Protein cause glial differentiation of Human Neural Stem Cell, Stem cell and development 2006, 15:381–389.
Kwak, Y-D, E. Choumkina and K. Sugaya: Amyloid precursor protein is involved in staurosporine induced glial differentiation of neural progenitor cells, Biochem Biophys Res Commun, 2006, 344 (1) 431-7.
Kwak, Y-D and K. Sugaya: RNA Interference in Human NTera-2/D1 Cell lines using Human U6 Promoter-based siRNA PCR Products, Biotechnology and Bioprocess Engineering, 2006, in press.
K. Sugaya: Possible stem cell therapy for Alzheimer’s disease and its future direction. IN Modern Medical Treatment in Neurology. Edited by I Kanazawa and H. Shibazaki and H. Tougi, Brains Network, Japan, 2005, pp108-114
J.S. Pulido and K. Sugaya: Papel de las celulas madre en la degeneracion macular asociada a la edad. IN Degeneracion macular asocial a la edad. Edited by J. Mones and Gomez-Ula, Prous Science, Barcelona, Spain, 2005, pp 343-350
K. Sugaya: Stem cell strategies for Alzheimer’s disease. IN Recent progress in Alzheimer’s and Parkinson’s diseases, Edited by Israel Hanin, Ramon Cacabelos and Abraham Fisher, Taylor & Francis, London and New York, 2005, pp 183-190.
K. Sugaya Possible use of autologous stem cell therapies for Alzheimer's disease. Curr Alzheimer Res. 2005 Jul; 2(3):367-76.
Qu, T., X. Dong, I. Sugaya, A. Vaghani, J. Pulido and K. Sugaya:Bromodeoxyuridine increases multipotency of human bone marrow-derived stem cells. Restor Neurol Neurosci. 2004; 22(6):459-68.
Kwak, Y-D., H. Koike and K. Sugaya: RNA interference with small hairpin RNAs transcribed from human U6 promoter-driven DNA vector. The Journal of Pharmacological Science. 2003, 93,214-217.
Dong, X., J. Pulido and K. Sugaya, Differentiation of human neural stem cells into retinal cells, NeuroReport. 2003 14: 143-6.
Sugaya, K., Research Strategy for Understanding Neuronal Plasticity and Degeneration. Psychiatrica et Neurologica Japonica. 2003 105 (1): 43-46
Sugaya, K Stem cell strategies in neuropsychiatric disorders. In strategies and mechanisms for cognitive dysfunction in psychiatric diseases. IN: New Age of Psychiatric Treatments, Nakayama-Shoten Co., Ltd. 2003, 248-256
Sugaya, K. Stem cell strategies, future and beyond, Seishin Shinkeikagaku Zasshi, 2003, 105(1) 68-80
Sugaya, K. Stem Cell Therapy for Alzheimer’s Disease. In Alzheimer's Disease - The Basics. A Physician's Guide to the Practical Management, Ralph W. Richter and Brigitte Richter, Editors; Humana Press, 2003, pp 289-300
Sugaya, K. Stem cell biology under pathological condition. The Journal Cellular and Molecular Life Science. 2003, 60: 1891-1902.
Sugaya, K. Current topics in stem cell research. Pharmacia, 2003, 39:103-107.
Sugaya, K, Potential use of stem cells in neuroreplacement therapies for neurodegenerative disease. International Review of Cytology, 2003, 228: 1-23,.
Sugaya, K. Neurodevelopment hypothesis of schizophrenia and genes. Schizophrenia Frontier, 2003 4(1): 32-36.
Sugaya, K, Qu, T., C. Brannen and M. Kim: Human neural stem cell transplantation improves cognitive function in aged rats. Mapping the Progress of Alzheimer’s and Parkinson’s Disease, Kluwer Academic/Plenum Publishers, 2002 pp229-234.
T. Uz, T. Qu, K.Sugaya and H Manev: Neuronal expression of arylalkylamin N-acetyltransferase (AANAT) mRNA in the rat brain. Neuroscience Research 2002, 42: 309-316.
H.M. Kim, T. Qu, V. Kriho, P. Lacor, N. Smalheiser, G.D. Pappas, A. Guidotti, E. Costa and K. Sugaya: Reelin function in neural stem cell biology. Proc Natl Acad Sci U S A, 2002 99: 4020-5.
Sugaya, K: Human neural stem cell transplantation as a future therapy for neurodegenerative disease. Brain Science, 2001, 23:882-884
Sugaya, K: Glial activation in aging and its pathological implication. Folia Pharmacologica Japonica 2001, 118:251-257
Sugaya, K and C. Brannen: Stem cell strategies for neuroreplacement therapy in Alzheimer’s disease. Medical Hypotheses, 2001, 57: 697-700.
Nicolle, M.M., J. Gonzalez, K. Sugaya, K. Baskerville, D. Bryan, K. Lund, M. Gallagher and M. MaKinney: Signature of hippocampal oxidative stress in aged spatial learning-impaired rodents, Neuroscience, 2001, 107:415-431.
Qu, T., C. Brannen, M. Kim and K. Sugaya: Human neural stem cells improve cognitive function of aged brain. NeuroReport. 12: 1127-1132, May 2001
Hernandez, D., K. Sugaya, T. Qu, E. McGowan, K. Duff and M. McKinney: Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-I and amyloid precursor protein mutant genes. NeuroReport. 12: 1377-1384, May 2001
Manev, H., Uz, T. Sugaya, K and Qu, T.: Putative role of neuronal 5-lipoxygenease in an aging brain. FSEB Journal, 2000 14: 1464-1469
Brannen C.L., and K. Sugaya: In vitro differentiation of multipotent human neural progenitors in serum-free medium. NeuroReport 2000, 11: 1123-1128
Fass U., K. Panickar, D. Personett, D. Bryan, K. Williams, J. Gonzales, K. Sugaya, M. McKinney: Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess. NeuroReport, 2000, 11: 0931-0936
Sugaya, K., T. Uz, V. Kumar and H. Manev: New anti-inflammatory treatment strategy in Alzheimer’s disease. Japan. J. Pharmacol., 2000, 82: 85-94
Sugaya, K. “The Herbal Preparations Kangenkaryu and Shen Yun Wan Reduce Brain Oxidative Stress” IN: Herbal Medicines for Neuro-psychiatryic Disease, edited by S. Kanba and E. Richelson. Seiwa Shoten Publishers, 1999 pp.117-125.
Kent C, Sugaya K, Bryan D, Personett D, McKinney M, Expression of superoxide dismutase messenger RNA in adult rat brain cholinergic neurons, Journal of Molecular Neuroscience, 12(1), 1-10, Feb 1999
Sugaya K, Greene R, Personett D, Robbins M, Kent C, Bryan D, Skiba E, Gallagher M, McKinney M. Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline. Neurobiology of Aging. 19(4): 351-61, 1998
Sugaya, K., S. Chou, S.-J. Xu and M. McKinney: Indicators of glial activation and brain oxidative stress after intraventricular infusion of endotoxin. Mol. Brain Res. 1998, 58:1-9
Sugaya, K., C. Clamp, D. Bryan, and M. McKinney: Messenger RNA for the m4 muscarinic receptor subtype is expressed in adult rat central cholinergic neurons. Mol. Brain Res.1997,50:305-313
Personett, D., K. Sugaya, D. Hammond, M. Robbins and M. McKinney: Use of capillary electrophoresis with laser-induced fluorescence detection to assess messenger ribonucleic acid molecules amplified by the polymerase chain reaction: Application in the cloning of cells. Electrophoresis, 1997, 18: 1750-1759.
Sugaya, K., Chouinard, M. and M. McKinney: Induction of manganese superoxide dismutase in BV-2 microglial cells. Neuro Report., 1997, 8: 3547-3551.
Sugaya, K., M. Chouinard and M. McKinney: Immunostimulation protects microglial cells from nitric oxide-mediated apoptosis. Neuro Report, 1997, 8:2241-2245.
Sugaya, K. M. Reeves and M. McKinney: Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus. Neurochem. International, 1997, 31:275-281.
Kumar, V., K. Sugaya, S. Saunders and J. Mechanic: Update on cholinergic drugs in Alzheimer’s Disease [Review]. Drugs of Today , 1996 32: 529-537
Sugaya, K. M. Chouinard, R. Greene, M. Robbins, D. Personett, M. Chouinard, J.T. Carter, C. Kent, M. Gallagher, and M. McKinney,: Molecular indices of neural and glial plasticity in the hippocampal formation in a rat model of the age-induced spatial memory impairment. J. Neurosci., 1996, 16: 3427-3443.
Personett, D., M. Chouinard, K. Sugaya, and M. McKinney: Simplified RT/PCR quantitation of gene transcripts in cultured neuroblastoma (SN49) and microglial (BV-2) cells using capillary electrophoresis and laser-induced fluorescence. J. of Neurosci. Res., 1996, 65: 77-91.
Sugaya, K., K. Matsunaga, Y. Sei and M. McKinney. “Kangenkaryu", chinese herb medicine, improved several symptoms in the animal model. IN: Alzheimer's and Parkinson's Diseases: Recent Advances, edited by Israel Hanin, Abraham Fisher, and Mitsuo Yoshida. Plenum Publishing Corporation. 1995 pp.411-pp.419.
Sugaya, K and M. McKinney. Nitric oxide synthase in a lesion model of Alzheimer’s disease. IN: Current Research in Alzheimer Therapy, edited by Ezio Giacobini and Robert Becker. Taylor & Francis. 1994 pp.304-pp.309
Kizuki, K., T. Suzuki, K. Sugaya, T. Noguchi and M. Kudo, Tissue kallikrein in rat and mouse neurons. Brazilian J. of Med. & Biol. Res., 1994, 27: 1891-1896
Sugaya, K. and M. McKinney. Nitric Oxide synthase gene expression in cholinergic neurons in the rat brain examined by combined immunocytochemistry and in situ hybridization histochemistry. Mol. Brain Res., 1994, 23: 111-125.
Sugaya, K., M. Takahashi, K. Kojima, T. Katoh, M. Ueki and K. Kubota. The Possibility of SUT-8701, a CCK-8 analog, as an anti-dementia Drug. IN: Proceeding of The Third International Conference on Alzheimer's Disease & Related Disorders. John Wiley & Sons, Ltd., Sussex, England. 1993 pp.577-pp.587
Takahashi, M., Sugaya, K., K. Kojima, T. Katoh, M. Ueki and K. Kubota. SUT-8701, cholecystokinin analogue, prevents the cholinergic degeneration in the rat cerebral cortex following the ibotenic acid basal forebrain lesion. Japan. J. Pharmacol. 1993, 61: 341-349
Sugaya, K. Nucleus basalis lesions decrease bungarotoxines binding site in rat cortex: SUT-8701, cholecystokinin octapeptide (CCK8) analog, has a potential as an antidementia drug for Alzheimer's disease. IN: Research Institute for Biosciences Science University of Tokyo Annual Report 1991. 1992 pp.23-pp.27
Takahashi, M., K. Sugaya, and K. Kubota. "Kangennkaryu" prevents the decrease of cholinergic markers following the nucleus basalis magnocellularis lesion. Japan. J. Pharmacol. 1992, 60: 307-310
Sugaya, K., M. Takahashi and K. Kubota. Cholecystokinin protects cholinergic neurons against basal forebrain lesion. Japan. J. Pharmacol. 1992, 59: 125-128
Sugaya, K. The Effect of "Kangenkaryu" on the dementia model animal. IN: Ecology in Food. (N. Igarashi and K. Namiki, eds.) Happy End Book, Tokyo, JAPAN 1991 pp. 97-pp. 102
Sugaya, K. Abnormal aging in central nervous system-- Nicotinic receptor subtypes in the human cortex. IN: Research Institute for Biosciences Science University of Tokyo Annual Report 1990. 1991 pp.24-pp.28
Takahashi, M., T. Katoh, M. Ueki, K. Kubota and K. Sugaya. Is it possible to use SUT compounds, CCK-8 analogs, as an anti-dementia drug? Japan. J. Neuropsycho-Pharmacol. 1991, 11:6 354
Sugaya, K., M. Downen and E. Giacobini. Nucleus basalis lesion decrease bungarotoxins binding site in rat cortex. Neuro Report 1991, 2:177-180
Sugaya, K., E. Giacobini and V. Chiappinelli. Nicotinic acetylcholine receptor subtypes in human cortex: Changes in Alzheimer's disease. J. Neuroscience Res. 1990, 26: 349-359.
Giacobini, E., R. J. Elble and K. Sugaya. Markers of cholinergic dysfunction in Alzheimer disease. IN: Alzheimer Disease Current Research in Early Diagnosis. (R.E. Becker, E. Giacobini, eds.) Taylor & Francis New York Inc. 1990 pp.137-pp.156
Sugaya, K., E. Giacobini, V. Chiappinelli and R. Struble. Subtypes of nicotinic receptor in human cortex. selective changes in Alzheimer disease. Proceed. Alz. Parkinson's Dis. Symp. Kyoto, Japan, Plenum Publishing (M. Yoshida, ed. ) 1990.
Sugaya, K. Patho-physiological studies of Alzheimer's disease. IN: Research Institute for Biosciences Science University of Tokyo Annual Report 1989. 1990 pp.22-pp.23
Downen, M., K. Sugaya, S.P. Arneric and E. Giacobini. Time course of alteration ACh synthesis and release and alpha-bungarotoxin binding in rat cortex following ibotenic acid lesion of the basal forebrain. IN: Novel Approaches to the Treatment of Alzheimer's Disease. Adv. in Behavioral Biology -Vol.36 (E.M. Meyer, J.W. impkins and J. Yamamoto, eds.), Plenum Press: New York, 1989 pp.255-pp.268
Tang, Z-C, P. DeSarno, K. Sugaya and E. Giacobini. The effect of huperzin-A, new cholinesterase inhibitor, of the central cholinergic system of the rat. J. Neuroscience Res. 1989, 24: 276-285
Kubota, K., K. Sugaya, Y. Koizumi and M. Toda, Cholecystokinin antagonism by anthramycin, benzodiazepine antibiotic, in the central nervous system in mice. Brain Res. 1989, 485: 62-66.
Kubota, K., K. Sugaya and K. Hotta. Effect of cimetidine on prostanoid production in the gastro in corpus specimen from rats. Japan. J. Pharmacol. 1988, 48: 491-498.
Sugaya, K., M. O. Maimets, and K. Kubota, 2-Deoxy d-[14C]-glucose study of the interaction of caerulein apomorphine. Japan. J. Pharmacol. 1988, 48: 131-136.
Sugaya, K. and K. Kubota, Autoradiographic demonstration of the antagonism of anthramycine diazepam against cholecystokinin in the mouse brain using the [14C]-2-deoxy glucose method. Japan. J. Pharmacol. 1988, 48: 1-6.
Sugaya, K.: Study of the antagonism between cholecystokinin and benzodiazepines. 1988, Ph.D. thesis
Sugaya, K., I. Matsuda and K. Kubota, Possible involvement of CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain. Japan. J. Pharmacol. 1987, 43: 67-71.
Kubota, K., F.Y. Sun, K. Sugaya and N. Sunagane, Reversal of antinociceptive effect of caerulein by benzodiazepine. J. Pharmacobiodyn. 1986, 9: 428-431.
Kubota, K., K. Sugaya, I. Matsuda, M. Itonaga and F. Y. Sun, Cholecystokinin antagonism by benzodiazepines: a new approach to the mechanism of action of benzodiazepine. J. Pharmacobiodyn. 1986, 9: 100
Kubota, K., I. Matsuda, K. Sugaya and T. Uruno, Cholecystokinin antagonism by benzodiazepine in the food intake in mice. Physiology Behavior 1986, 36: 175-178.
Kubota, K., K. Sugaya, I. Matsuda, Y. Matsuoka and M. Itonaga, Caerulein antagonism by benzodiazepine in the food intake in mice. Japan. J. Pharmacol. 1986, 39: 120-122.
Sugaya, K., I. Matsuda and K. Kubota, Inhibition of Hypothermic Effect of Cholecystokinin by benzodiazepine and benzodiazepine antagonist, Ro 15-1788, in mice. Japan. J. Pharmacol. 1985, 39: 277-279.
Kubota, K., K. Sugaya, F. Fujii, M. Itonaga and N. Sunagane, Inhibition of cholecystokinin response in the gallbladder by dibenamine and it protection by benzodiazepines, Japan. J. Pharmacol. 1985, 39: 274-276.
Kubota, K., K. Sugaya, I. Matsuda, Y. Matsuoka and Y. Terawaki, Reversal of antinociceptive effect of cholecystokinin by benzodiazepine and benzodiazepine antagonist, Ro 15-1788. Japan. J. Pharmacol. 1985, 37: 101-105.
Kubota, K., K. Sugaya, N. Sunagane, I. Matsuda and T. Uruno, Cholecystokinin antagonism by benzodiazepine in the contractile response of the isolated guinea pig gallbladder. Eur. J. Pharmacol. 1985, 110: 225-231.
